The game Mass Effect 2 has been out for about a month already, but it is still not very playable in stereoscopic 3D mode with 3D Vision, so a lot of people are waiting for official profile or prefer to play the game in normal 2D mode. The problem is that there are quite a lot of issues when you play the game in S3D mode that actually make it uncomfortable, but with a bit of tweaking you can at least make it look much better in stereo 3D mode and make it playable. I’m talking about issues like having 2D crosshair along with other object markers rendered in 3D, but separating too much. There are some issues with Dynamic shadows as usual, some rare problems with lights that may create halos around your characters and so on. The good news is that Nvidia seems to be working with the game developer on the issues and the bad is that there are still no fixes or a profile for the game so you can stick to what you can currently do.
You should start by disabling the Dynamic Shadows, they do create some visual issues in quite a lot of games being played in stereoscopic 3D mode as they do here. Another option you better disable is the Film Grain, it is not much of an issue maker, but I cant imagine how this makes your game graphics look better. As I already mentioned the game has a 2D crosshair, but with some custom convergence settings you can make it usable and you can also enable the Nvidia lasersight by pressing CTRL + F12 to make aiming better. There is a workaround that can remove the game crosshair completely, but that solution might cause you some stability issues, so you better not resort to it and with the custom settings you should not have to remove the crosshair as it is completely bearable. My custom convergence settings are optimized for depth, there are no pop-out effects as this seems to create some graphical issues and you can set the depth level somewhere between 5% (preferably) and 15% for best results. The focus of these custom setting is to try to eliminate most of the graphical issues and by doing that there is a sacrifice with the depth level, but it is still some depth left to make the game more enjoyable when played in S3D mode. Optionally you can also increase the brightness a bit to lets say +2 to get better visibility through the 3D Vision active shutter glasses in darker areas, but that is only if things seem too dark for you. As usual please leave your comments if you try the custom settings.